![]() ![]() ![]() Leg discomfort in patients with critical limb ischemia/chronic limb-threatening ischemia (CLI/CLTI) that has progressed from intermittent claudication with exertion to chronic rest pain will be present. The amount of dead tissue from gangrene can be significant, and it can spread quickly over a large portion of the body. Enough blood cannot flow to the legs, feet, arms, or hands because of plaque buildup in the limbs. Blood flow is impeded by blood vessel inflammation. During exercise, this restricts blood flow to the lower leg. The popliteal artery is compressed by the body’s calf muscle. Blood flow is restricted when the blood vessels contract. The blood arteries in the fingers and toes are affected by cold temperatures. Several cases of people developing dry gangrene in their fingers and toes as a result of COVID-19-related blood coagulation issues have been reported (coagulopathy) The body’s capacity to fight off infections can be affected by chemotherapy, radiation, and several illnesses, including the human immunodeficiency virus (HIV). The pressure of extra weight on the arteries can decrease blood flow, increase the risk of infection, and hinder the healing of wounds. Gangrene risk is increased by any condition that damages the skin and underlying tissue, including frostbite. Damage to blood vessels can cause a part of the body’s blood flow to slow down or stop. Blood arteries may eventually get damaged by high blood sugar levels. Narrowed arteries like atherosclerosis cause plaque buildup that interrupts the body’s blood flow. People who have particular underlying medical disorders that affect their blood vessels are more vulnerable to gangrene. Atherosclerosis or peripheral artery disease can lead to reduced blood flow Risk Factors to Gangrene Medical conditions that affect blood circulation.Although rare, other necrotizing soft tissue infections often have a distinct entry point due to trauma or problems at the surgical site after surgery ![]() Gangrene may develop if the bacteria infect tissues and are left untreated. Open wounds that allow bacteria to enter the body might arise from gunshot wounds or crushing injuries suffered in automobile accidents. An injury such as severe and deep wounds.Gangrene can develop as a result of an untreated bacterial infection ![]()
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